Posted on February 20, 2015January 29, 2015 by Loren SoeiroPsyBlog: This is What Depression Does to The Brain’s ‘Disappointment Circuit’ Does the tendency to “see the glass half empty” have a neurological basis? http://www.spring.org.uk/2015/01/this-is-what-depression-does-to-the-brains-disappointment-circuit.php